Facial wrinkles can be of two types: expression or static.
The wrinkles of expression are those produced by the contraction of the muscles when gesturing. We have wrinkles in front, frown lines, wrinkles around the eyes (crow’s feet) or wrinkles around the mouth (bar code).
Gravitational or static wrinkles are those produced by the aging of the skin (chronological or photo-aging). The most common are in the area of the nasolabial fold (on both sides of the mouth).
The wrinkles of expression of the forehead, between the eyebrows, around the eyes and some of the neck are treated by the injection of substances that block the facial muscles.
Static wrinkles are treated by injecting filler materials such as hyaluronic acid, among others.
Cortesy of Merz
The pharmacological effect of injections of substances that block the facial muscles takes place at the level of the neuromuscular junction. In this region of transition between the peripheral nerve and the muscle occurs the release of acetylcholine, a neurotransmitter necessary to produce muscle contraction. Injections act locally by blocking the release of acetylcholine, which translates into temporary muscle paralysis.
Injections of substances that block the facial muscles are applied directly to the wrinkles to be treated, such as fine lines around the eyes, forehead and between the eyebrows.
Its effect relaxes the movement of the muscles, minimizing wrinkles if they are marked, eliminating them if they are soft and even wrinkles can be prevented
The effect of injections relaxes the movement of the muscles. If the substance is injected in very early stages of the wrinkle, its appearance can be avoided.
The results can begin to be seen after 24 or 48 hours of its application and last approximately 3 to 6 months.
The results depend on the severity of the lines and the reaction of the body to the product. It is observed that the muscle moves less or does not move and therefore the wrinkles are attenuated or eliminated according to their severity.
Patients can continue their normal life after receiving the injections.
The injections to eliminate, attenuate or prevent wrinkles is a painless treatment.
It also has the advantages of not needing a recovery time or care and unlike other skin rejuvenation treatments, there are no problems in exposing the skin to the sun.
The results of the injection of substances that block the facial muscles to eliminate, attenuate or prevent wrinkles have a temporary duration, between three to six months, after which time the dose should be renewed if you want to maintain the result.
In general, the side effects for the treatment of wrinkles are mild and transient and do not limit the performance of successive infiltrations.
The side effects of the injection of substances that block the facial muscles for the treatment of wrinkles can be:
Based on the recommendations of the Pharmacovigilance working group (PhVWP), the European Medicines Agency (EMEA), in coordination with other European Regulatory Agencies, recommends the following:
